![]() Targeted approaches such as candidate gene sequencing 2 and qPCR 3, 4 have been used to uncover the genetic determinants of traits evolved by GS. Studies aimed at uncovering the genetic architecture of strains evolved by genome shuffling may thus contribute to an understanding of the genetic basis of complex and industrially relevant traits. GS and other evolutionary engineering methodologies are notably useful to enhance complex phenotypes for which a detailed molecular level understanding is lacking. It has been widely and successfully adopted for the evolutionary engineering of industrial traits in microbes 1. Evolve Mutations 2 Torrent Trial Traits In Our results reveal cohorts of strongly correlated mutations, suggesting prevalent genetic hitchhiking and the presence of pre-existing founder mutations.įrom the patterns of apparent selection and the results of direct phenotypic assays, our results identify key driver mutations and deleterious hitchhikers.Ĭonclusions We use these data to propose a model of inhibitor tolerance in our GS mutants. ![]() ![]() Evolve Mutations 2 Torrent Trial Traits In.
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